Chronic pain is one of the most disabling medical conditions globally, yet, to date, we lack a satisfying theoretical framework for research and clinical practice. Over the prior decades, several frameworks have been presented with biopsychosocial models as the most promising. However, in translation to clinical practice, these models are often applied in an overly reductionist manner, leaving much to be desired. In particular, they often fail to characterize the complexities and dynamics of the lived experience of chronic pain. Recently, (...) an enactive, affordance-based approach has been proposed, opening up new ways to view chronic pain. This model characterizes how the persistence of pain alters a person’s field of affordances: the unfolding set of action possibilities that a person perceives as available to them. The affordance-based model provides a promising perspective on chronic pain as it allows for a systematic investigation of the interactive relation between patients and their environment, including characteristic alterations in the experience of their bodies and the space they inhabit. To help bridge the gap from philosophy to clinical practice, we unpack in this paper the core concepts of an affordance-based approach to chronic pain and their clinical implications, highlighting aspects that have so far received insufficient attention. We do so with an analogy to playing video games, as we consider such comparative illustration a useful tool to convey the complex concepts in an affordance-based model and further explore central aspects of the lived experience of chronic pain. (shrink)

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

In the Classical Museum of University College, Dublin, there is a small black glaze Attic cup belonging to the Vienna-Cup group. It is 7·7 cm high and 13·8 cm in diameter. It has been broken and repaired at some time and parts of the handles are modern, and some of the lip is restored. It might be as well to point out that the foot is whole and has never been broken. The cup is almost wholly black, except for the (...) insides of the handles, the outside edge and resting surface of the foot, and the centre of the foot which are all reserved. It looks quite normal, but if one picks it up and tilts it, one hears a rattling, almost a ringing, sound from the foot which is not only hollow, but contains three small clay pellets, as revealed by an X-ray examination. There is no vent hole.The cup is to be dated to some time within the period 475–450 B.C. I do not know of any parallels among the Vienna-Cup group, but there is another black glaze cup in Leningrad which belongs to the Kalliades-Brygos group and which has a hollow foot and rattling pellets just like those on the Dublin cup. The Kalliades-Brygos group is generally dated to between 500 and 470 B.C. This would mean that the Leningrad cup is probably earlier than the Dublin example, but they both still belong to the first half of the fifth century. The relevance to the discussion of a fragmentary foot in Toronto from a cup of Cup-Type C painted by Skythes c. 500 B.C., is debatable. In the case of this foot there is a hollow channel around the edge as in the Dublin and Leningrad examples, but it differs from them in that there was originally a small rectangular hole in it, the left side of which is preserved. The hole was apparently never closed, so that it is unlikely that the hollow held pellets as did the others, or if it did, there might have been a temporary stopper of, say, unbaked clay. The hole is a puzzle, for it seems too big to be merely a vent hole. (shrink)

We examine the question of how many Boolean algebras, distinct up to isomorphism, that are quotients of the powerset of the naturals by Borel ideals, can be proved to exist in ZFC alone. The maximum possible value is easily seen to be the cardinality of the continuum $2^{\aleph_{0}}$ ; earlier work by Ilijas Farah had shown that this was the value in models of Martin's Maximum or some similar forcing axiom, but it was open whether there could be fewer in (...) models of the Continuum Hypothesis. We develop and apply a new technique for constructing many ideals whose quotients must be nonisomorphic in any model of ZFC. The technique depends on isolating a kind of ideal, called shallow, that can be distinguished from the ideal of all finite sets even after any isomorphic embedding, and then piecing together various copies of the ideal of all finite sets using distinct shallow ideals. In this way we are able to demonstrate that there are continuum-many distinct quotients by Borel ideals, indeed by analytic P-ideals, and in fact that there is in an appropriate sense a Borel embedding of the Vitali equivalence relation into the equivalence relation of isomorphism of quotients by analytic P-ideals. We also show that there is an uncountable definable wellordered collection of Borel ideals with distinct quotients. (shrink)

We examine the question of how many Boolean algebras, distinct up to isomorphism, that are quotients of the powerset of the naturals by Borel ideals, can be proved to exist in ZFC alone. The maximum possible value is easily seen to be the cardinality of the continuum $2^{\aleph_{0}}$ ; earlier work by Ilijas Farah had shown that this was the value in models of Martin's Maximum or some similar forcing axiom, but it was open whether there could be fewer in (...) models of the Continuum Hypothesis. We develop and apply a new technique for constructing many ideals whose quotients must be nonisomorphic in any model of ZFC. The technique depends on isolating a kind of ideal, called shallow, that can be distinguished from the ideal of all finite sets even after any isomorphic embedding, and then piecing together various copies of the ideal of all finite sets using distinct shallow ideals. In this way we are able to demonstrate that there are continuum-many distinct quotients by Borel ideals, indeed by analytic P-ideals, and in fact that there is in an appropriate sense a Borel embedding of the Vitali equivalence relation into the equivalence relation of isomorphism of quotients by analytic P-ideals. We also show that there is an uncountable definable wellordered collection of Borel ideals with distinct quotients. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Clarifying the Relationship Between Vice and Mental Disorder: Vice as Manifestation of a Psychological DysfunctionMichael B. First (bio)KeywordsDSM-IV, psychiatric diagnosis, impulse control disorders, sexually violent predator commitmentIndividuals generally present for psychiatric evaluation for one of two reasons: either because they themselves are suffering from a psychiatric symptom that causes distress (e.g., severe panic) or impairs their ability to function effectively (e.g., memory loss), or else they are brought to (...) clinical attention because their behavior or attitudes are considered by others to be problematic. There are a wide range of behaviors that fall into this second category. In some cases, the individual is pressured to seek treatment because of the negative impact that a behavior has on a relationship partner (e.g., sexual dysfunction, anger outbursts) or an employer (e.g., excessive alcohol use). Often, however, the external trigger for a clinical evaluation falls under Sadler’s definition of vice, that is, criminal (illegal) behaviors or attitudes that could be considered “wrongful” or “immoral” in the social arena because the behavior violates the law or an important social more.Given that one of the most important goals of the Diagnostic and Statistical Manual of Mental Disorders (DSM) is to facilitate clinical practice (First et al. 2004) and in doing so provide a diagnostic code to cover any patient that might present himself or herself to a mental health professional, the DSM has evolved over its various editions to become a veritable laundry list of psychological and behavioral ills, some of which may constitute a violation of the rights of others or society. The DSM-III (and its successors) have adopted a descriptive approach wherein disorders are defined in terms of their presenting surface symptomatology, which was necessitated by the field’s lack of knowledge about the underlying etiology of mental disorders. Given this reliance on presenting symptoms, it is therefore inevitable that some disorders are defined in terms of behaviors that can be considered vices. For example, impaired impulse [End Page 35] control often leads to acting out behavior that, at its mildest is inappropriate, and at its most severe is destructive to self and others. Many of the disorders cited by Sadler as being vice-laden fall into this category, namely, pyromania (failure to resist impulses to set fires), kleptomania (failure to resist impulses to steal), intermittent explosive disorder (failure to resist aggressive impulses), certain forms of substance abuse (i.e., those involving possession and use of illegal substances) and paraphilias (i.e., those involving nonconsenting victims).It is important to clarify from the outset that the criteria for determining whether a behavior is a “vice” (i.e., whether it is illegal or immoral) is not equivalent to the criteria for determining whether a behavior is indicative of a mental disorder. According to the DSM-IV-TR definition, a mental disorder is conceptualized as a “clinically significant behavioral or psychological syndrome or pattern that occurs in an individual and that is associated with present distress (e.g., a painful symptom) or disability (i.e., impairment in one or more important areas of functioning) or with a significantly increased risk of suffering death, pain, disability, or an important loss of freedom” (American Psychiatric Association [APA] 2000, xxxi). The definition warns against considering “deviant behavior[s] (e.g., political, religious, or sexual)” and “conflicts that are primarily between the individual and society” to be evidence of mental disorder except in those cases in which the “deviance or conflict is a symptom of a dysfunction in the individual.” Thus, when considering whether a particular “vice” behavior is a component of a mental disorder, it is crucial to determine whether the behavior is a manifestation of an underlying psychological dysfunction, such as a dysfunction in impulse control. If so, it may potentially be appropriate for that individual to be treated as “medically ill” in addition to, or instead of, being treated simply as a criminal.Let us examine some illustrative examples of cases that demonstrate the relationship between vice and mental disorders and the different ways in which the legal and mental health systems might deal with such cases. Consider the case of an individual who breaks... (shrink)

This volume, originally published as a special issue of Pragmatics and Society (issue 3:2, 2012), draws together complementary perspectives on the social and interactional life of evidentiality.

This volume, originally published as a special issue of Pragmatics and Society (issue 3:2, 2012), draws together complementary perspectives on the social and interactional life of evidentiality.

The increasing effort, both lay and academic, to encourage a transition from an “I-It” to an “I-Thou” relation to nature is located within a typology of ways of “knowing nature.” This typology provides the context for a particular understanding of human conversation which sees the relation as a cyclical process of “immersion” and “realization” from which a model of the dialectic between “I-It” and “I-Thou” relations to nature can be developed. This model can be used to identify practical measures that (...) can be taken as first steps toward a balance between these relations, both in general and in the context of science-oriented nature conservation organizations such as English Nature in Britain. (shrink)

In this book, Michael Arbib, a researcher in artificial intelligence and brain theory, joins forces with Mary Hesse, a philosopher of science, to present an integrated account of how humans 'construct' reality through interaction with the social and physical world around them. The book is a major expansion of the Gifford Lectures delivered by the authors at the University of Edinburgh in the autumn of 1983. The authors reconcile a theory of the individual's construction of reality as a network (...) of schemas 'in the head' with an account of the social construction of language, science, ideology and religion to provide an integrated schema-theoretic view of human knowledge. The authors still find scope for lively debate, particularly in their discussion of free will and of the reality of God. The book integrates an accessible exposition of background information with a cumulative marshalling of evidence to address fundamental questions concerning human action in the world and the nature of ultimate reality. (shrink)

A variant of realizability for Heyting arithmetic which validates Church’s thesis with uniqueness condition, but not the general form of Church’s thesis, was introduced by Lifschitz (Proc Am Math Soc 73:101–106, 1979). A Lifschitz counterpart to Kleene’s realizability for functions (in Baire space) was developed by van Oosten (J Symb Log 55:805–821, 1990). In that paper he also extended Lifschitz’ realizability to second order arithmetic. The objective here is to extend it to full intuitionistic Zermelo–Fraenkel set theory, IZF. The machinery (...) would also work for extensions of IZF with large set axioms. In addition to separating Church’s thesis with uniqueness condition from its general form in intuitionistic set theory, we also obtain several interesting corollaries. The interpretation repudiates a weak form of countable choice, ACω,ω, asserting that a countable family of inhabited sets of natural numbers has a choice function. ACω,ω is validated by ordinary Kleene realizability and is of course provable in ZF. On the other hand, a pivotal consequence of ACω,ω, namely that the sets of Cauchy reals and Dedekind reals are isomorphic, remains valid in this interpretation. Another interesting aspect of this realizability is that it validates the lesser limited principle of omniscience. (shrink)

This article offers a novel, conservative account of material constitution, one that incorporates sortal essentialism and features a theory of dominant sortals. It avoids coinciding objects, temporal parts, relativizations of identity, mereological essentialism, anti-essentialism, denials of the reality of the objects of our ordinary ontology, and other departures from the metaphysic implicit in ordinary ways of thinking. Defenses of the account against important objections are found in Burke 1997, 2003, and 2004, as well as in the often neglected six paragraphs (...) that conclude section V of this article. (shrink)

This seminal collection on the ethical issues associated with infectious disease is the first book to correct bioethics’ glaring neglect of this subject. Timely in view of public concern about SARS, AIDS, avian flu, bioterrorism and antibiotic resistance. Brings together new and classic papers by prominent figures. Tackles the ethical issues associated with issues such as quarantine, vaccination policy, pandemic planning, biodefense, wildlife disease and health care in developing countries.

Integrating large language models (LLMs) like GPT-4 into medical ethics is a novel concept, and understanding the effectiveness of these models in aiding ethicists with decision-making can have significant implications for the healthcare sector. Thus, the objective of this study was to evaluate the performance of GPT-4 in responding to complex medical ethical vignettes and to gauge its utility and limitations for aiding medical ethicists. Using a mixed-methods, cross-sectional survey approach, a panel of six ethicists assessed LLM-generated responses to eight (...) ethical vignettes. The main outcomes measured were relevance, reasoning, depth, technical and non-technical clarity, as well as acceptability of GPT-4’s responses. The readability of the responses was also assessed. Of the six metrics evaluating the effectiveness of GPT-4’s responses, the overall mean score was 4.1/5. GPT-4 was rated highest in providing technical (4.7/5) and non-technical clarity (4.4/5), whereas the lowest rated metrics were depth (3.8/5) and acceptability (3.8/5). There was poor-to-moderate inter-rater reliability characterised by an intraclass coefficient of 0.54 (95% CI: 0.30 to 0.71). Based on panellist feedback, GPT-4 was able to identify and articulate key ethical issues but struggled to appreciate the nuanced aspects of ethical dilemmas and misapplied certain moral principles. This study reveals limitations in the ability of GPT-4 to appreciate the depth and nuanced acceptability of real-world ethical dilemmas, particularly those that require a thorough understanding of relational complexities and context-specific values. Ongoing evaluation of LLM capabilities within medical ethics remains paramount, and further refinement is needed before it can be used effectively in clinical settings. (shrink)

Many terminally ill patients perceive themselves to be a burden to loved ones who care for them. The self-perception of being a burden can play a significant role in terminal patients’ decisions to take courses of action, such as ceasing life-sustaining treatment or requesting physician-assisted suicide, that hasten death. I will use the term ‘burden-based decision’ as a shorthand for cases in which a terminal patient’s perception that she is a burden to her loved ones influences her decision to hasten (...) death. When should we view a terminal patient’s inclination to make a burden-based decision to be an ethical problem or a failure of treatment? And when should we view it to be an acceptable response rather than a problem or failure? I argue here that such decisions are acceptable more often than many who write on this topic imply. (shrink)

Dion is a full-bodied man. Theon is that part of him which consists of all of him except his left foot. What becomes of Dion and Theon when Dion’s left foot is amputated? Employing the doctrine of sortal essentialism, I defend a surprising answer last defended by Chrysippus: that Dion survives while the seemingly unscathed Theon perishes. For replies to critics, see my publications of 1997 and (especially) 2004.

Integration of knowledge concerning circadian rhythms, metabolic networks, and sleep‐wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants (...) were identified in fruit fly. Consequently, non‐transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24‐hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems‐level investigations implementing integrated multi‐omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems. -/- . (shrink)

I aim to show that there are cases in which an ordinary material object exists intermittently. Afterwards there are a few words about the consequences of acknowledging such cases, but what is of more interest is the route by which the conclusion is reached. When deciding among competing descriptions of the cases considered, I have tried to reduce to a minimum the role of intuitive judgment, and I have based several arguments on "metaphysical principles," two of which I have defended.

This academic text features articles regarding paranormal, extraordinary, or fringe-science claims. It logically examines the claims of astrology; psychic ability; alternative medicine and health claims; after-death communication; cryptozoology; and faith healing, all from a skeptical perspective. Paranormal Claims is a compilation of some of the most eye-opening articles about pseudoscience and extraordinary claims that often reveal logical, scientific explanations, or an outright scam. These articles, steeped in skepticism, teach critical thinking when approaching courses in psychology, sociology, philosophy, education, or science.

On the most popular account of material constitution, it is common for a material object to coincide precisely with one or more other material objects, ones that are composed of just the same matter but differ from it in sort. I argue that there is nothing that could ground the alleged difference in sort and that the account must be rejected.

In this paper, I offer a novel, conservative solution to the puzzle of Tibbles the cat. I do not criticize the existing solutions or the theories within which they are embedded. I am content to offer an alternative, one that relies on the recently resurgent doctrine of Aristotelian essentialism. My solution, unlike some of its competitors, is applicable to the full range of cases in which, as with Tib and Tibbles, there is the threat of coinciding objects. In section 1, (...) I present the solution. In sections II-IV, I defend it against four objections. (shrink)

We develop a framework for assessing security market quality, relating five elements of market design to three metrics of market integrity and two metrics of market efficiency. We empirically implement this integrity–efficiency MQ framework by testing a hypothesis that trade-based ramping manipulation at the close raises execution costs on 24 security markets worldwide. Estimating a simultaneous equations model of ramping incidence, spreads, and the probability of deploying real-time surveillance, we show that quoted bid-ask spreads are positively related to the incidence (...) of MTC across seven liquidity deciles. The magnitude is economically significant; improving market integrity by cutting MTC in half reduces spreads 6–11 %. Allowing direct market access in conjunction with RTS, conducting auctions at the close, and developing regulations that require surveillance, all reduce MTC and thereby lower spreads, assuring better market integrity and enhancing market efficiency. Introducing circuit breakers or prohibiting shorts poses integrity–efficiency tradeoffs. (shrink)

Two experiments investigated whether infants represent goal‐directed actions of others in a way that allows them to draw inferences to unobserved states of affairs (such as unseen goal states or occluded obstacles). We measured looking times to assess violation of infants' expectations upon perceiving either a change in the actions of computer‐animated figures or in the context of such actions. The first experiment tested whether infants would attribute a goal to an action that they had not seen completed. The second (...) experiment tested whether infants would infer from an observed action the presence of an occluded object that functions as an obstacle. The looking time patterns of 12‐month‐olds indicated that they were able to make both types of inferences, while 9‐month‐olds failed in both tasks. These results demonstrate that, by the end of the first year of life, infants use the principle of rational action not only for the interpretation and prediction of goal‐directed actions, but also for making productive inferences about unseen aspects of their context. We discuss the underlying mechanisms that may be involved in the developmental change from 9 to 12 months of age in the ability to infer hypothetical (unseen) states of affairs in teleological action representations. (shrink)

A collection of essays by prominent physicists, biologists, geneticists, zoologists, philosophers and other thinkers about the relationship between science and philosophy, particularly the teleological versus the mechanistic explanation of the universe.

Over the last two or three decades, puzzles concerning vagueness, identity, and material constitution have led an increasing number of ontologists to “eliminate” at least some of the objects of folk ontology. In the book here reviewed, Trenton Merricks proposes to eliminate any and all material objects that lack nonredundant causal powers. The objects found lacking include statues, baseballs, planets, and all other inanimate macroscopica, including the masses and conjunctive objects favored by some other eliminativists. The objects found to possess (...) the requisite powers include human persons, who are taken to be human organisms, other conscious organisms, such as dogs and dolphins, and the microscopica of which organisms are composed. Merricks doesn’t assume that there are physical simples. But he does assume that there is at least one level of microscopica, and he uses ‘atoms’ as a convenient term for the microscopica of some unspecified level. As regards organisms that lack consciousness, Merricks is agnostic. (shrink)